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    CSRP2 cysteine and glycine rich protein 2 [ Homo sapiens (human) ]

    Gene ID: 1466, updated on 3-Apr-2024

    Summary

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    Official Symbol
    CSRP2provided by HGNC
    Official Full Name
    cysteine and glycine rich protein 2provided by HGNC
    Primary source
    HGNC:HGNC:2470
    See related
    Ensembl:ENSG00000175183 MIM:601871; AllianceGenome:HGNC:2470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRP2; LMO5; SmLIM
    Summary
    CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
    Expression
    Ubiquitous expression in esophagus (RPKM 37.2), placenta (RPKM 35.3) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    12q21.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (76858709..76879019, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (76836580..76856889, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (77252489..77272799, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6679 Neighboring gene Sharpr-MPRA regulatory region 20 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:77158059-77158901 Neighboring gene RWD domain containing 1 pseudogene 3 Neighboring gene zinc finger DHHC-type palmitoyltransferase 17 Neighboring gene MPRA-validated peak1846 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4673 Neighboring gene NANOG hESC enhancer GRCh37_chr12:77268223-77268724 Neighboring gene uncharacterized LOC124902971 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4675 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:77313616-77314124 Neighboring gene Sharpr-MPRA regulatory region 9474 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:77329846-77331045 Neighboring gene NANOG hESC enhancer GRCh37_chr12:77358407-77359020 Neighboring gene RAN binding protein 1 pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:77425832-77427031 Neighboring gene E2F transcription factor 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6683 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4676 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:77459297-77460003

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cysteine and glycine-rich protein 2 (CSRP2) transcript levels correlate with leukemia relapse and leukemia-free survival in adults with B-cell acute lymphoblastic leukemia and normal cytogenetics. Wang SJ, et al. Oncotarget, 2017 May 30. PMID 28415593, Free PMC Article
    2. Hypoxia promotes breast cancer cell invasion through HIF-1α-mediated up-regulation of the invadopodial actin bundling protein CSRP2. Hoffmann C, et al. Sci Rep, 2018 Jul 5. PMID 29976963, Free PMC Article
    3. Interleukin-10 activation of the interleukin-10E1 pathway and tissue inhibitor of metalloproteinase-1 expression is enhanced by proteasome inhibitors in primary prostate tumor lines. Stearns ME, et al. Mol Cancer Res, 2003 Jul. PMID 12861049
    4. Role of CRP2-MRTF interaction in functions of myofibroblasts. Hayashi K, et al. Cell Struct Funct, 2023. PMID 37164693, Free PMC Article
    5. CSRP2 suppresses colorectal cancer progression via p130Cas/Rac1 axis-meditated ERK, PAK, and HIPPO signaling pathways. Chen L, et al. Theranostics, 2020. PMID 33042270, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Significance of the p38MAPK-CRP2 axis in myofibroblastic phenotypic transition.
      Title: Significance of the p38MAPK-CRP2 axis in myofibroblastic phenotypic transition.
    2. Role of CRP2-MRTF interaction in functions of myofibroblasts.
      Title: Role of CRP2-MRTF interaction in functions of myofibroblasts.
    3. CSRP2 suppresses colorectal cancer progression via p130Cas/Rac1 axis-meditated ERK, PAK, and HIPPO signaling pathways.
      Title: CSRP2 suppresses colorectal cancer progression via p130Cas/Rac1 axis-meditated ERK, PAK, and HIPPO signaling pathways.
    4. Study showed that CSRP2, an invadopodial actin bundling protein, is upregulated by hypoxia in various breast cancer cell lines, as well as in pre-clinical and clinical breast tumor specimens and functionally characterized two hypoxia responsive elements within the proximal promoter of CSRP2 gene which are targeted by hypoxia-inducible factor-1 (HIF-1) and required for promoter transactivation in response to hypoxia.
      Title: Hypoxia promotes breast cancer cell invasion through HIF-1α-mediated up-regulation of the invadopodial actin bundling protein CSRP2.
    5. CSRP2 promoted cell proliferation, cell-cycle progression, in vitro colony formation and cell migration ability. Abnormal CSRP2 expression was associated with resistance to chemotherapy; sensitivity was restored by down-regulating CSRP2 expression.
      Title: Cysteine and glycine-rich protein 2 (CSRP2) transcript levels correlate with leukemia relapse and leukemia-free survival in adults with B-cell acute lymphoblastic leukemia and normal cytogenetics.
    6. the effect of proteasome inhibition on IL-10 activation of the IL-10E1 pathway [Il-10E1]
      Title: Interleukin-10 activation of the interleukin-10E1 pathway and tissue inhibitor of metalloproteinase-1 expression is enhanced by proteasome inhibitors in primary prostate tumor lines.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actinin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of muscle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cysteine and glycine-rich protein 2
    Names
    LIM domain only 5, smooth muscle
    LIM domain only protein 5
    LMO-5
    cysteine-rich protein 2
    epididymis secretory sperm binding protein
    smooth muscle cell LIM protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300965.2 → NP_001287894.1  cysteine and glycine-rich protein 2 isoform b

      See identical proteins and their annotated locations for NP_001287894.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes isoform b. Variants 1-5 all encode the same isoform (b).
      Source sequence(s)
      AC124784, BC000992, BX461295, CN408330
      Consensus CDS
      CCDS9015.1
      UniProtKB/Swiss-Prot
      Q16527, Q93030
      UniProtKB/TrEMBL
      A0A024RBB5, F8VQR7
      Related
      ENSP00000450056.1, ENST00000546966.5
      Conserved Domains (2) summary
      cd09480
      Location:9 → 63
      LIM1_CRP2; The first LIM domain of Cysteine Rich Protein 2 (CRP2)
      cd09840
      Location:119 → 172
      LIM2_CRP2; The second LIM domain of Cysteine Rich Protein 2 (CRP2)

    2. NM_001321.3 → NP_001312.1  cysteine and glycine-rich protein 2 isoform b

      See identical proteins and their annotated locations for NP_001312.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform b. Variants 1-5 all encode the same isoform (b).
      Source sequence(s)
      AC124784, BC000992, BX461295
      Consensus CDS
      CCDS9015.1
      UniProtKB/Swiss-Prot
      Q16527, Q93030
      UniProtKB/TrEMBL
      A0A024RBB5, F8VQR7
      Related
      ENSP00000310901.5, ENST00000311083.10
      Conserved Domains (2) summary
      cd09480
      Location:9 → 63
      LIM1_CRP2; The first LIM domain of Cysteine Rich Protein 2 (CRP2)
      cd09840
      Location:119 → 172
      LIM2_CRP2; The second LIM domain of Cysteine Rich Protein 2 (CRP2)

    3. NM_001413535.1 → NP_001400464.1  cysteine and glycine-rich protein 2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC124784
      UniProtKB/Swiss-Prot
      Q16527, Q93030
      UniProtKB/TrEMBL
      A0A024RBB5

    4. NM_001413537.1 → NP_001400466.1  cysteine and glycine-rich protein 2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC124784
      UniProtKB/Swiss-Prot
      Q16527, Q93030
      UniProtKB/TrEMBL
      A0A024RBB5

    5. NM_001413538.1 → NP_001400467.1  cysteine and glycine-rich protein 2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC124784
      UniProtKB/Swiss-Prot
      Q16527, Q93030
      UniProtKB/TrEMBL
      A0A024RBB5

    6. NM_001413539.1 → NP_001400468.1  cysteine and glycine-rich protein 2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC124784
      UniProtKB/TrEMBL
      F8VW96
      Related
      ENSP00000449824.1, ENST00000552330.5

    7. NM_001413540.1 → NP_001400469.1  cysteine and glycine-rich protein 2 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC124784

    8. NM_001413541.1 → NP_001400470.1  cysteine and glycine-rich protein 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC124784

    9. NM_001413542.1 → NP_001400471.1  cysteine and glycine-rich protein 2 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC124784

    RNA

    1. NR_182159.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124784

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      76858709..76879019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428395.1 → XP_047284351.1  cysteine and glycine-rich protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q16527, Q93030
      UniProtKB/TrEMBL
      A0A024RBB5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      76836580..76856889 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371216.1 → XP_054227191.1  cysteine and glycine-rich protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q16527, Q93030
      UniProtKB/TrEMBL
      A0A024RBB5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16527.3 GenPept UniProtKB/Swiss-Prot:Q16527

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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